Recent Advances in Opioid Deterrence

29
1304
Deterrence

The science of pain is intriguing.  It wasn’t all that long ago that a shot of whiskey was the pain reliever of choice.  Modern medicine has since become acquainted with aspirin and ibuprofen for treating minor aches, various forms of anesthesia for use in operations, and different formulations of opium, for addressing chronic pain.  Chronic pain has proven particularly challenging though, because opioid based medicine has proven to be highly addictive.  That’s why research on (1) a new class of non-opioid pain killer reported on at ScienceMag.org, and (2) an anti-heroin vaccine developed by The Scripps Institute (“TSI”), hold out such promise.

Deterrence

Non-Opioid Pain Relief

Researchers report they’ve discovered a new molecule that halts pain and eliminates addiction, while limiting interference with healthy cell function.  This finding could have a huge impact because pain and addiction typically have similar biochemical roots, making treatment difficult without affecting normal cell activity.  For example, opioids interrupt pain by affecting certain enzymes known as ACs (adenylyl cyclases), but that in turn makes other functions of the cell skyrocket, triggering addiction.  This new process avoids that problem by targeting only one of the ACs (out of 10), minimizing negative changes in the cells.

Researchers came upon this molecule after studying a plant compound known as Forskolin, which actually supercharges the AC enzyme.  However, drugs that increase an enzyme’s output can often be used to decrease it as well, because they interact with the same target site.  In doing so, the scientists were able to create a compound that reduces sensitivity to pain with the same potency as an opioid, but without the addictive side effects.

Anti-Heroin Vaccine

We at InRecovery magazine originally wrote about TSI back in May, regarding an innovative new medical technique they were working on to help the brain forget it’s addicted.  It seems they’ve now come up with another great prospect.

Working in conjunction with Virginia Commonwealth University, TSI has created an anti-heroin vaccine that works by exposing a person’s immune system to the heroin molecule.  This, in turn, teaches the immune system to produce antibodies against the drug, preventing the heroin molecules from reaching the brain and causing feelings of euphoria.  Testing done on primates has demonstrated effects lasting as long as 8 months.  The vaccine, 8 years in the making, only seems to work for heroin and not opioid based pain killers, at the moment, but research continues.

Unfortunately, neither of these positive developments will be available at your local drug store any time soon.  Scientists are still  working through some of the pitfalls, and need to conduct additional studies prior to clinical trials.  However, given the inherent problems with opioids and the need to treat chronic pain, these preliminary results are certainly welcome news.

29 COMMENTS

  1. Hi would you mind stating which blog platform you’re using? I’m planning to start my own blog soon but I’m having a difficult time choosing to go with WordPress.

  2. This sounds wonderful, but what is the comparison to Vivitrol? Vivitrol retrains the brain in relation to addiction to both heroin and opiate pain killers as well as alcohol. How would this development be better?

    • It sounds like the vaccine would be a better option because it lasts as long as 8 months. Oppose to Vivitrol. Since Vivitrol is a monthly injection the addict might not get the injection.

  3. I don’t even understand how I ended up here, however I believed this publish was once great. I do not know who you’re but certainly you are going to a well-known blogger if you are not already 😉 Cheers!

  4. I just came right here from some other web address relating to Arvind Pandit Kansas and considered I might as well check this out. I really like what I see therefore I am just following you. Looking forward to finding out about the blog yet again.

  5. I was speaking to a friend of my own on this and even about lucky patcher for android too. I think you made some very good points in this article, we’re looking forward to keep reading information from you.

  6. That is very interesting, You are an overly professional blogger. I’ve joined your rss feed and sit up for looking for more of your wonderful post. Additionally, I have shared your web site in my social networks!

  7. My partner and I absolutely adore your site and find many of your blog posts to be exactly what I’m seeking. Do you offer people to post content material for you? I wouldn’t mind composing a post regarding free instagram followers or even on some of the topics you’re posting about on this site. Cool place!

  8. Our LGV (Large Goods Vehicle) HGV training is based in East London, and our LGV/ HGV courses are taught by qualified DVSA LGV & HGV trainers. LGV was formerly known as HGV, where it used to be referred to as HGV Class 2 (now called LGV Category C) and HGV class 1 (Now called LGV Category C+E).

  9. Thanks a bunch for this excellent posting! I genuinely enjoyed it.I’ll be sure to bookmark your website and will often return in the future. I would like to encourage that you keep going with your fine writing, even write about car accident attorney too, have a great day!

  10. Would you be interested in trading links or maybe guest authoring a blog article or vice-versa? My site discusses a lot of the same subjects as yours and I believe we could greatly benefit from each other. If you’re interested feel free to shoot me an email. I look forward to hearing from you! Awesome blog by the way!

  11. Thanks a lot for your amazing content! I certainly enjoyed learning about.I will make sure to take note of the website and will often return in the future. I would love to encourage that you continue the great work, possibly talk about lawn mower deals as well, have a fantastic day!

  12. Thanks a ton for writing this info, I bookmarked the web page. I’m furthermore attempting to find data regarding electric heaters, have you any idea the place where I could find a thing like that? I’ll come back quickly!

  13. My spouse and I totally like your website and find almost all of your discussions to be exactly what I am seeking. Would you offer people to create information for you? I would not mind publishing an article relating to movies to watch or possibly on most of the things you write about on this website. Awesome page!

  14. My family and I totally adore your site and find many of the blogposts to be exactly I am interested in. Would you offer other people to post information for you? I wouldn’t mind publishing a piece of text about where can i buy bitcoins or perhaps on many of the things you are writing about here. Awesome website!

  15. You’re entirely correct. I really liked reviewing this info and I will certainly get back for more as quickly as possible. My own internet site is dealing with standard shipping, you could have a look if you happen to be interested in that.

  16. Youre so cool! I dont suppose Ive learn anything like this before. So nice to search out anyone with some unique thoughts on this subject. realy thank you for beginning this up. this website is something that is wanted on the internet, someone with a bit of originality. useful job for bringing one thing new to the internet!

LEAVE A REPLY

Please enter your comment!
Please enter your name here